Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis - AgroParisTech Access content directly
Journal Articles Frontiers in Chemistry Year : 2018

Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

Louis Mouterde
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Florent Allais

Abstract

The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized-by using a combination of a Design of Experiment and a standard optimization approach-a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86-99% and in 85-97% yields.
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hal-02527502 , version 1 (01-04-2020)

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Louis Mouterde, Florent Allais. Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis. Frontiers in Chemistry, 2018, 6, pp.426. ⟨10.3389/fchem.2018.00426⟩. ⟨hal-02527502⟩

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