Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions
Résumé
Hypothalamic neuropeptides named hypocretin/orexins which were identified in 1998 regulate critical functions such as wakefulness in the central nervous system. These past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation, intestinal motility, hormone secretion, lipolyze and reproduction functions. Associated to these peripheral functions, it was found that orexins and their receptors were involved in various diseases such as acute/chronic inflammation, metabolic syndrome and cancers. The present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease, multiple sclerosis and septic shock, obesity and digestive cancers.
Mots clés
Alain Couvineau 0000-0003-2912-5168 Thierry Voisin 0000-0002-4320-5183 Pascal Nicole 0000-0002-0004-616X Valerie Gratio 0000-0001-8563-3293 Anne Blais 0000-0002-0897-7612 Invited article Externally peer reviewed Peer-review report's scientific quality classification Grade A (Excellent): 0 Grade B (Very good): 0 Orexin Neuropeptide G-protein coupled receptor superfamily Inflammation Metabolic syndrome Cancer
Alain Couvineau 0000-0003-2912-5168
Thierry Voisin 0000-0002-4320-5183
Pascal Nicole 0000-0002-0004-616X
Valerie Gratio 0000-0001-8563-3293
Anne Blais 0000-0002-0897-7612 Invited article
Externally peer reviewed Peer-review report's scientific quality classification Grade A (Excellent): 0 Grade B (Very good): 0 Orexin
Neuropeptide
G-protein coupled receptor superfamily
Inflammation
Metabolic syndrome
Cancer
Domaines
Sciences du Vivant [q-bio]
Fichier principal
Orexins A promising target to digestive cancers, inflammation,.pdf (2.33 Mo)
Télécharger le fichier
Origine | Fichiers éditeurs autorisés sur une archive ouverte |
---|