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Journal Articles Pathogens Year : 2022

Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France

1 Hôpital Foch [Suresnes]
2 IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
3 P3CELL - Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250
4 CHU Reims - Centre Hospitalier Universitaire de Reims
5 BIOPATH Laboratoires
6 BIO ARD’AISNE
7 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
8 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
9 Centre Hospitalier Antibes - Juan-les-Pins
10 AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]
11 HIA - Hopital d'instruction des armées Sainte-Anne [Toulon]
12 CHU Henri Mondor [Créteil]
13 CHU Nantes - Centre hospitalier universitaire de Nantes
14 CHU Poitiers - Centre hospitalier universitaire de Poitiers
15 CHU Trousseau [Tours]
16 ULB - Université libre de Bruxelles
17 IGR - Institut Gustave Roussy
18 Microbiologie
19 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
20 Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë
21 CHU Necker - Enfants Malades [AP-HP]
22 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
23 CHV - Centre Hospitalier de Versailles André Mignot
24 Hôpital Avicenne [AP-HP]
25 CHU Caen
26 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital
27 BRM - ARN régulateurs bactériens et médecine
28 Centre hospitalier [Valenciennes, Nord]
29 Centre hospitalier de Dieppe
30 Hôpital d'Instruction des Armées Begin
31 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
E. Farfour
  • Function : Correspondent author
A. Poisson
  • Function : Author
Cécile Le Brun
  • Function : Author
  • PersonId : 968811
C. Isnard
  • Function : Author

Abstract

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were $E.\ coli$ (72.0%), $Klebsiella\ pneumoniae$ (9.7%), $Proteus\ mirabilis$ (5.8%), and $Enterobacter\ cloacae$ complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in $P.\ mirabilis$ to 19.5% in $K.\ pneumoniae$, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.
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hal-03633007 , version 1 (06-04-2022)

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E. Farfour, L. Dortet, Thomas Guillard, N. Chatelain, A. Poisson, et al.. Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France. Pathogens, 2022, 11 (3), pp.356. ⟨10.3390/pathogens11030356⟩. ⟨hal-03633007⟩
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