%0 Journal Article %T Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance %+ Physiologie de la Nutrition et du Comportement Alimentaire (PNCA) %A Blouet, Clémence %A Mariotti, François %A Azzout-Marniche, Dalila, D. %A Mathe, Véronique %A Mikogami, Takashi %A Tomé, Daniel, D. %A Huneau, Jean-François %< avec comité de lecture %@ 0891-5849 %J Free Radical Biology and Medicine %I Elsevier %V 42 %N 7 %P 1089 - 1097 %8 2007-04-01 %D 2007 %R 10.1016/j.freeradbiomed.2007.01.006 %M 17349935 %Z Life Sciences [q-bio]/Food and Nutrition %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN] %Z Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] %Z Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] %Z Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism %Z Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]Journal articles %X Diets that promote oxidative stress favor impairment in glucose homeostasis. In this context, increasing the cysteine intake may be beneficial by maintaining glutathione status. We have investigated the effects of dietary cysteine on oxidative stress and glucose homeostasis in rats fed a high-sucrose (HS) diet. Rats were assigned for 6 weeks to a standard diet or to HS diets in which the protein source was either an alpha-lactalbumin-rich whey concentrate (a cysteine-rich protein) or the total milk proteins alone or supplemented with 5.8 or 20 g N-acetylcysteine per kilogram of food. Increasing the cysteine intake prevented HS-induced oxidative stress, as assessed by blood and tissue glutathione and carbonyl levels. At the same time, the HS-induced glucose intolerance, impaired postprandial glycemic control, and decrease in muscle and liver insulin-induced activation of insulin receptor substrate 1 and Akt were prevented by increasing the level of dietary cysteine, a major original finding. Of great interest was the observation that all beneficial effects of cysteine supplementation were duplicated by the consumption of a cysteine-rich protein. These data show that increasing the cysteine intake limits HS-induced impairment of glucose homeostasis and suggest that these effects are mediated by a reduction in oxidative stress. %G English %L hal-01611432 %U https://agroparistech.hal.science/hal-01611432 %~ AGROPARISTECH %~ INRA %~ AGREENIUM %~ PNCA %~ INRAE