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cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Xavier Fant , Emilie Durieu , Gaëtan Chicanne , Bernard Payrastre , Diego Sbrissa , et al.
Molecular Pharmacology, 2014, 85 (3), pp.441-50. ⟨10.1124/mol.113.090837⟩
Journal articles inserm-01012086v1
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Nadège Loaëc , Eletta Attanasio , Benoît Villiers , Emilie Durieu , Tania Tahtouh , et al.
Marine drugs, 2017, 15 (10), pp.316 -. ⟨10.3390/md15100316⟩
Journal articles hal-01640115v1

Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors

Putey Aurelien , Fournet Guy , Olivier Lozach , Lionel Perrin , Meijer Laurent , et al.
European Journal of Medicinal Chemistry, 2014, 83, pp.617-629
Journal articles hal-01147615v1
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From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , et al.
Molecules, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩
Journal articles hal-03867783v1
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Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Pascal Bonnet , Mohamed Souab , et al.
European Journal of Medicinal Chemistry, 2018, 154, pp.101-109. ⟨10.1016/j.ejmech.2018.04.056⟩
Journal articles hal-03408667v1
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Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

M. Hedidi , W. Erb , G. Bentabed-Ababsa , Floris Chevallier , L. Picot , et al.
Tetrahedron, 2016, 72 (41), pp.6467--6476. ⟨10.1016/j.tet.2016.08.056⟩
Journal articles hal-01381138v1

Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors

Camille Déliko Dago , Wacothon Karime Coulibaly , Yves-Alain Bekro , Janat A. Mamyrbekova-Bekro , Beatrice Foll-Josselin , et al.
Medicinal Chemistry Research, 2016, 25 (12), pp.2940--2958. ⟨10.1007/s00044-016-1719-3⟩
Journal articles hal-01414293v1

Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

Madani Hedidi , Julien Maillard , William Erb , Frédéric Lassagne , Yury Halauko , et al.
Tetrahedron, 2016, 72 (39), pp.6467 - 6476. ⟨10.1016/j.tet.2016.08.056⟩
Journal articles hal-03875302v1

Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors

Mehdi A. Beniddir , Erell Le Borgne , Bogdan I. Iorga , Nadège Loaëc , Olivier Lozach , et al.
Journal of Natural Products, 2014, 77 (5), pp.1117-1122. ⟨10.1021/np400856h⟩
Journal articles hal-01162685v1

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Cédric Logé , Mélanie Pénichon , et al.
European Journal of Medicinal Chemistry, 2015, 105, pp.80-105. ⟨10.1016/j.ejmech.2015.10.004⟩
Journal articles hal-02389861v1
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The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases

Maciej Masłyk , Monika Janeczko , Aleksandra Martyna , Sławomir Czernik , Małgorzata Tokarska-Rodak , et al.
Molecules, 2019, 24 (1), pp.153. ⟨10.3390/molecules24010153⟩
Journal articles hal-02046526v1
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Synthesis of bioactive 2-(arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff reaction or Cu- catalyzed intramolecular C-S bond formation

Damien Hédou , Carole Dubouilh-Benard , N. Loaëc , L. Meijer , Corinne Fruit , et al.
Molecules, 2016, 21 (6), pp.794. ⟨10.3390/molecules21060794⟩
Journal articles hal-02046212v1
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Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Damien Hédou , Julien Godeau , N. Loaëc , L. Meijer , Corinne Fruit , et al.
Molecules, 2016, 21 (5), pp.578. ⟨10.3390/molecules21050578⟩
Journal articles hal-02046213v1
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6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

C. Delehouzé , S. Leverrier-Penna , F. Le Cann , A. Comte , M. Jacquard-Fevai , et al.
Scientific Reports, 2017, 7 (1), pp.12931. ⟨10.1038/s41598-017-12788-4⟩
Journal articles hal-01616456v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet , et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével , et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1
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From drug screening to target deconvolution: A target-based drug discovery pipeline using Leishmania casein kinase 1 isoform 2 to identify compounds with anti-leishmanial activity

Emilie Durieu , Eric Prina , Olivier Leclercq , Nassima Oumata , Nicolas Gaboriaud-Kolar , et al.
Antimicrobial Agents and Chemotherapy, 2016, ⟨10.1128/AAC.00021-16⟩
Journal articles hal-01299756v1
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2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , et al.
Tetrahedron, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩
Journal articles hal-01774406v1

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors

Christophe Labrière , Olivier Lozach , Mélina Blairvacq , Laurent Meijer , Catherine Guillou
European Journal of Medicinal Chemistry, 2016, 124, pp.920 - 934. ⟨10.1016/j.ejmech.2016.08.069⟩
Journal articles hal-01517780v1
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Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129

Marion Navarri , C. Jégou , Arnaud Bondon , Sandrine Pottier , Stéphane Bach , et al.
Marine drugs, 2017, 15 (4), ⟨10.3390/md15040111⟩
Journal articles hal-01518044v1
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Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.

Rajâa Boulahjar , Aziz Ouach , Stéphane Bourg , Pascal Bonnet , Olivier Lozach , et al.
European Journal of Medicinal Chemistry, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
Journal articles hal-01212495v1
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Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents

Anne Cecília Nascimento da Cruz , Dalci José Brondani , Temístocles Ítalo de Santana , Lucas Oliveira da Silva , Elizabeth Fernanda da Oliveira Borba , et al.
Pharmaceuticals, 2019, 12 (4), pp.169. ⟨10.3390/ph12040169⟩
Journal articles hal-03864455v1
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New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Solène Guihéneuf , Ludovic Paquin , François Carreaux , Emilie Durieu , Thierry Roisnel , et al.
Molecular Diversity, 2014, 18 (2), pp.375-88. ⟨10.1007/s11030-014-9509-7⟩
Journal articles hal-01017003v1
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Fused Systems Based on 2-Aminopyrimidines: Synthesis Combining Deprotolithiation-in situ Zincation with N -Arylation Reactions and Biological Properties

Madani Hedidi , Julien Maillard , William Erb , Frédéric Lassagne , Yury S Halauko , et al.
European Journal of Organic Chemistry, 2017, 2017 (39), pp.5903-5915. ⟨10.1002/ejoc.201701004⟩
Journal articles hal-01624382v1

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

Yvonnick Loidreau , Emmanuel Deau , Pascal Marchand , Marie-Renée Nourrisson , Cédric Logé , et al.
European Journal of Medicinal Chemistry, 2015, 92, pp.124-134. ⟨10.1016/j.ejmech.2014.12.038⟩
Journal articles hal-01135195v1
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A combined experimental and theoretical study of the thermal [3+2] cycloaddition of carbonyl ylides with activated alkenes

Samira Hamza-Reguig , Ghenia Bentabed-Ababsa , Luis R Domingo , Mar Ríos-Gutiérrez , Stephanie Philippot , et al.
Journal of Molecular Structure, 2018, 1157, pp.276-287. ⟨10.1016/j.molstruc.2017.12.052⟩
Journal articles hal-01695551v2

Tampering with Cell Division by Using Small-Molecule Inhibitors of CDK-CKS Protein Interactions

Amel Hamdi , Aurélien Lesnard , Peggy Suzanne , Thomas Robert , Maria A. Miteva , et al.
ChemBioChem, 2015, 16 (3), pp.432-439. ⟨10.1002/cbic.201402579⟩
Journal articles istex hal-02043908v1